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# CITATION file created with {cffr} R package
# See also: https://docs.ropensci.org/cffr/
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cff-version: 1.2.0
message: 'To cite package "biotmle" in publications use:'
type: software
license: MIT
title: 'biotmle: Targeted Learning with Moderated Statistics for Biomarker Discovery'
version: 1.17.1
doi: 10.18129/B9.bioc.biotmle
identifiers:
- type: doi
  value: 10.32614/CRAN.package.biotmle
abstract: Tools for differential expression biomarker discovery based on microarray
  and next-generation sequencing data that leverage efficient semiparametric estimators
  of the average treatment effect for variable importance analysis. Estimation and
  inference of the (marginal) average treatment effects of potential biomarkers are
  computed by targeted minimum loss-based estimation, with joint, stable inference
  constructed across all biomarkers using a generalization of moderated statistics
  for use with the estimated efficient influence function. The procedure accommodates
  the use of ensemble machine learning for the estimation of nuisance functions.
authors:
- family-names: Hejazi
  given-names: Nima
  email: nh@nimahejazi.org
  orcid: https://orcid.org/0000-0002-7127-2789
- family-names: Hubbard
  given-names: Alan
  email: hubbard@berkeley.edu
  orcid: https://orcid.org/0000-0002-3769-0127
- family-names: Laan
  given-names: Mark
  name-particle: van der
  email: laan@stat.berkeley.edu
  orcid: https://orcid.org/0000-0003-1432-5511
preferred-citation:
  type: manual
  title: 'biotmle: Targeted Learning with moderated statistics for biomarker discovery'
  authors:
  - family-names: Hejazi
    given-names: Nima S
  - family-names: Laan
    given-names: Mark J
    name-particle: van der
  - family-names: Hubbard
    given-names: Alan E
  year: '2024'
  notes: R package version 1.17.1
  doi: 10.18129/B9.bioc.biotmle
  url: https://bioconductor.org/packages/biotmle
repository: https://nhejazi.r-universe.dev
repository-code: https://github.com/nhejazi/biotmle
commit: b13f8b4582fd1ebe4ca4e0dd9ce8452957728c41
url: https://code.nimahejazi.org/biotmle
contact:
- family-names: Hejazi
  given-names: Nima
  email: nh@nimahejazi.org
  orcid: https://orcid.org/0000-0002-7127-2789
references:
- type: article
  title: 'biotmle: Targeted Learning for Biomarker Discovery'
  authors:
  - family-names: Hejazi
    given-names: Nima S
  - family-names: Cai
    given-names: Weixin
  - family-names: Hubbard
    given-names: Alan E
  journal: The Journal of Open Source Software
  year: '2017'
  doi: 10.21105/joss.00295
  url: https://doi.org/10.21105/joss.00295
- type: article
  title: A generalization of moderated statistics to data adaptive semiparametric
    estimation in high-dimensional biology
  authors:
  - family-names: Hejazi
    given-names: Nima S
  - family-names: Boileau
    given-names: Philippe
  - family-names: Laan
    given-names: Mark J
    name-particle: van der
  - family-names: Hubbard
    given-names: Alan E
  journal: arxiv
  year: '2021'
  url: https://arxiv.org/abs/1710.05451