Please cite the following works when using the 'biotmle' software package, including both the software tool and the article describing the statistical methodology. Hejazi NS, van der Laan MJ, Hubbard AE (2024). _biotmle: Targeted Learning with moderated statistics for biomarker discovery_. doi:10.18129/B9.bioc.biotmle , R package version 1.17.1, . A BibTeX entry for LaTeX users is @Manual{, title = {{biotmle}: Targeted Learning with moderated statistics for biomarker discovery}, author = {Nima S Hejazi and Mark J {van der Laan} and Alan E Hubbard}, year = {2024}, note = {R package version 1.17.1}, doi = {10.18129/B9.bioc.biotmle}, url = {https://bioconductor.org/packages/biotmle}, } Hejazi NS, Cai W, Hubbard AE (2017). “biotmle: Targeted Learning for Biomarker Discovery.” _The Journal of Open Source Software_. doi:10.21105/joss.00295 , . A BibTeX entry for LaTeX users is @Article{, journal = {The Journal of Open Source Software}, title = {biotmle: Targeted Learning for Biomarker Discovery}, author = {Nima S Hejazi and Weixin Cai and Alan E Hubbard}, year = {2017}, doi = {10.21105/joss.00295}, url = {https://doi.org/10.21105/joss.00295}, } Hejazi NS, Boileau P, van der Laan MJ, Hubbard AE (2021). “A generalization of moderated statistics to data adaptive semiparametric estimation in high-dimensional biology.” _arxiv_. . A BibTeX entry for LaTeX users is @Article{, journal = {arxiv}, title = {A generalization of moderated statistics to data adaptive semiparametric estimation in high-dimensional biology}, author = {Nima S Hejazi and Philippe Boileau and Mark J {van der Laan} and Alan E Hubbard}, year = {2021}, url = {https://arxiv.org/abs/1710.05451}, }